Drug facts
MoleculeDoxycycline Hyclate
Generics already compete: 33 makers on the market. 80 A-rated products from 33 makers substitute at the counter.
Vibra-Tabs was first approved by the FDA before 1982 under NDA 050533; the application holder is Pfizer Laboratories Div Pfizer Inc. The Orange Book lists NDA 050533 as discontinued.
The latest NADAC for DOXYCYCLINE HYCLATE 75 MG TAB is $0.55 per unit (as of 10/28/2026).
Holder Pfizer Laboratories Div Pfizer IncApplication NDA 050533Approved before 1982
01Patents and exclusivity
When competition can legally begin. A generic can launch once both exclusivity and the last listed patent expire, unless a court or settlement says otherwise.
- Latest patent
- No Vibra-Tabs patent listed in the Orange Book Orange Book
- Later patents, other products
- Doryx 12/23/2034 Orange Book
02Competition
- Generics
- 33 generic makers Orange Book
- First generic approved
- before 1982 Orange Book
Every listingEach listing and maker behind the generics count.
Price erosionHow NADAC moves as generics enter.
PrescribersWho prescribes it, from Medicare data.
Available in the full Doxycycline Hyclate profile.See what is included
03Supply and price
- FDA drug shortage
- ClearNot on the current shortage list FDA shortages
- NADAC
- $0.55 per unitDOXYCYCLINE HYCLATE 75 MG TAB, mid-priced of 5 strengths, as of 10/28/2026 CMS NADAC
- Latest recall
- 09/29/2025Class II, Doxycycline Hyclate, Acella Pharmaceuticals, LLC FDA enforcement
04Product
- Application holder
- Pfizer Laboratories Div Pfizer Inc Orange Book
- Application
- NDA 050533 Orange Book
- First approved
- before 1982 Orange Book
- Dosage forms
- capsule; injectable; tablet; tablet, delayed release
- Routes
- injection, oral
- Other brand names
- ActiclateDoryx MpcDoxy 100Doxy 200
- Status
- NDA 050533 discontinued Orange Book
Sources: FDA Orange Book, FDA Purple Book, FDA drug shortages, FDA enforcement reports and CMS NADAC, read through QOPE. Not medical or legal advice.